77.5 B+
SS-31
Also known as: Elamipretide, MTP-131, Bendavia
Strong Clinical Evidence Research Chemical
Research Evidence 90.0/100
Safety Profile 65.0/100
31 Clinical Trials
Unknown: 1 PHASE3: 3 PHASE2, PHASE3: 1 PHASE2: 11 PHASE1, PHASE2: 5 PHASE1: 9 NA: 1
- An Intermediate Size Expanded Access Protocol of Elamipretide Unknown Phase AVAILABLE Stealth BioTherapeutics Inc.
- ReNEW:Phase 3 Study of Efficacy, Safety & Pharmacokinetics of Subcutaneous Injections of Elamipretide in Subjects With Dry Age-Related Macular Degeneration (Dry AMD) PHASE3 ACTIVE_NOT_RECRUITING Stealth BioTherapeutics Inc.
- Study to Evaluate Efficacy and Safety of Elamipretide in Subjects With Primary Mitochondrial Disease From Nuclear DNA Mutations (nPMD) PHASE3 COMPLETED Stealth BioTherapeutics Inc.
- A Trial to Evaluate Safety and Efficacy of Elamipretide Primary Mitochondrial Myopathy Followed by Open-Label Extension PHASE3 TERMINATED Stealth BioTherapeutics Inc.
- A Trial to Evaluate Safety, Tolerability and Efficacy of Elamipretide in Subjects With Barth Syndrome PHASE2, PHASE3 COMPLETED Stealth BioTherapeutics Inc.
Showing 5 of 31 trials.
20 Research Papers
- Mechanisms of Anti-Oxidants, N-Acetylcysteine and Elamipretide (SS-31), on Ozone-Induced Airway Hyperresponsiveness and Mucus Hypersecretion. Lung unknown
- Disruption of hippocampal mitochondrial function underlies opioid-induced postoperative cognitive dysfunction in aged rats. bioRxiv unknown
- Restoring cardiolipin homeostasis mitigates cerebral ischemia-reperfusion injury by suppressing ATG5-mediated neuronal autophagy-dependent ferroptosis. J Adv Res unknown
- Early targets and progressive deterioration in cardiac performance in response to chronically modified cardiac troponin I. Am J Physiol Heart Circ Physiol unknown
- Breaking a mitochondrial danger-STING feed-forward amplifier preserves alveolar-capillary architecture and dampens interferon-chemokine signaling in acute lung injury. Tissue Cell unknown
Showing 5 of 20 papers by citation count.
FDA Data
Not FDA-Approved
SS-31 has not been evaluated by the FDA for safety or efficacy. It is not approved for human therapeutic use in the United States.
Frequently Asked Questions
Is SS-31 FDA approved?
No, SS-31 has not been approved by the FDA for human therapeutic use. It is sold as a research chemical.
How many clinical trials has SS-31 been studied in?
SS-31 has been studied in 31 registered clinical trials. CheckPeptides tracks phase, status, and sponsor data for each trial.
What is the trust score for SS-31?
SS-31 has a CheckPeptides trust score of 77.5/100 (grade: B+). This score is based on clinical trial volume, research paper quality, FDA data, and evidence classification.
Last verified: April 7, 2026
Quick Facts
- Classification
- Mitochondria-targeted antioxidant peptide
- Molecular Weight
- 639.8 Da
- PubChem
- CID 11764719 ↗
- Regulatory Status
- N/A
Score Breakdown
Research Evidence 90.0/100
Safety Profile 65.0/100
Evidence Summary
- Clinical Trials
- 31
- Research Papers
- 20
- Trust Score
- 77.5/100
- Grade
- B+