70.0 B
Melanotan II
Also known as: MTII, MT-2
Strong Clinical Evidence Category 2 Restricted
Research Evidence 90.0/100
Safety Profile 50.0/100
38 Clinical Trials
Unknown: 2 PHASE4: 7 PHASE3: 3 PHASE2, PHASE3: 1 PHASE2: 6 PHASE1, PHASE2: 3 PHASE1: 3 NA: 12 EARLY_PHASE1: 1
- RRT With a Cytokine Absorption Filter (oXiris ®) in Patients With Septic Shock Unknown Phase COMPLETED Clinica CES
- Melatonin Receptor Agonist and Peripheral Biological Markers Unknown Phase COMPLETED National Science and Technology Council, Taiwan
- The Iron and Muscle Study PHASE4 COMPLETED King's College Hospital NHS Trust
- Efficacy and Safety of Rituximab to That of Calcineurin Inhibitors in Children With Steroid Resistant Nephrotic Syndrome PHASE4 UNKNOWN Nilratan Sircar Medical College
- An Open-label Study to Identify Molecular Markers of Steroid Resistance PHASE4 TERMINATED Massachusetts General Hospital
Showing 5 of 38 trials.
20 Research Papers
- Oxidative stress impairs the expansion of regulatory T cells in active vitiligo via dysregulated CGRP-RAMP1-Gαi3 signaling. Free Radic Biol Med unknown
- Beyond "YouTube clips": a qualitative study of manual therapy educators' perceptions of 3D technology in MT education. J Man Manip Ther unknown
- Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukaemia/lymphoma (X): withanolides from Physalis pruinosa. Nat Prod Res unknown
- N-Acylaminoethyltetrahydroquinolines: A new class of melatonin receptor ligands with in vivo activity on glioblastoma. Eur J Med Chem unknown
- International maritime organization, we may have a problem - ballast water treatment triggers global concerns with antimicrobial resistant bacteria. Mar Pollut Bull unknown
Showing 5 of 20 papers by citation count.
FDA Data
Not FDA-Approved
Melanotan II has not been evaluated by the FDA for safety or efficacy. It is not approved for human therapeutic use in the United States.
This peptide is classified as FDA Category 2 — it is prohibited from use in compounding pharmacies effective 2024. Obtaining it requires unregulated sources.
Frequently Asked Questions
Is Melanotan II FDA approved?
No, Melanotan II is not FDA approved. It is classified as FDA Category 2 and is banned from compounding pharmacies.
How many clinical trials has Melanotan II been studied in?
Melanotan II has been studied in 38 registered clinical trials. CheckPeptides tracks phase, status, and sponsor data for each trial.
What is the trust score for Melanotan II?
Melanotan II has a CheckPeptides trust score of 70.0/100 (grade: B). This score is based on clinical trial volume, research paper quality, FDA data, and evidence classification.
Last verified: April 7, 2026
Quick Facts
- Classification
- Melanocortin receptor agonist
- Molecular Weight
- 1024.2 Da
- PubChem
- CID 92432 ↗
- Regulatory Status
- N/A
Score Breakdown
Research Evidence 90.0/100
Safety Profile 50.0/100
Evidence Summary
- Clinical Trials
- 38
- Research Papers
- 20
- Trust Score
- 70.0/100
- Grade
- B